Evaluation of Hepatic Enzymes and its association with Glycemic Control among Non - Obese Type 2 Diabetes Mellitus Patients

Abstract

Background: Liver plays a key role in regulating the carbohydrate, lipid and protein metabolisms and in maintaining the blood glucose levels in the body. Oxidative stress plays an additional role in causing liver damage in diabetic patients, increasing damage to the hepatic cells further worsens the glycemic control causing hyperglycemia and complications of diabetes. Aim: To Estimate the liver enzymes in patients with Type 2 Diabetes Mellitus and its correlation with glycemic control among non-obese Type 2 Diabetes mellitus patients. Material and method: A Cross sectional analytical study conducted in a tertiary care hospital and Research center from January 2019 to July 2020 and 96 patients were included in the study. Patients were divided into 2 groups of 48 each, Group 1 consists of Type 2 Diabetes mellitus patients on oral hypoglycemic drugs and Type 2 Diabetes mellitus patients on insulin therapy in Group 2. Liver enzymes AST, ALT, GGT, ALP and HbA1C was estimated in both the groups. The data obtained was subjected to appropriate statistical analysis. Results: The participants in both the groups had BMI of <30kg/m. The mean levels with Standard error (SE) of hepatic enzymes and HbA1C in Group I and Group II was AST (26.38±2.3and 27.75±1.7), ALT (25.54±3.1and 26.38±1.97), GGT (33.60±4.5 and 27.48±2.4), ALP (101.23±4.7and 107.08±4.0) and HbA1C(9.96±0.29 and 9.26±0.24)respectively. Conclusion: Liver enzymes could be within normal limits in non-obese Type 2 Diabetes Mellitus patients on regular physical activity and treatment, USG abdomen along with Liver enzymes estimation to be considered during follow-up of non-obese Type 2 Diabetes Mellitus patients with normal serum triglyceride (TG) levels.