Evaluation of Effect of Adding Dextrose to Levobupivacaine, Compared to Levobupivacaine Plain in Subarachnoid Block for Lower Limb and Lower Abdominal Surgeries

Abstract

Context: The search of a drug which can give the perfect balance of sensory and motor block with minimal side effects has always missed researchers. We have conducted a study to study the efficacy of adding dextrose to levobupivacaine and try to find an alternate to the routinely used bupivacaine. Aims: Evaluation of effect of adding dextrose to levobupivacaine, compared to levobupivacaine plain in terms of onset and duration of sensory and Motor blockade; Quality of analgesia.(VAS score). Settings and Design: Open Labelled Study Methods and Material: 140 patients admitted for elective surgeries, during the period of January 2017 to December 2017. Group L: Hyperbaric Levobupivacaine with 150 mg dextrose.(0.3 ml of 50% dextrose), volume is 3.3 ml; Group p: Plain levo Bupivacaine. (volume is 3.3 ml). Statistical analysis used: Student t test (two tailed, independent),. Chi-square/Fisher Exact test. Results: In Group II Time to two segmentsensory level regression was significantly more (188.89±22.32) compared to Group I (118.96±33.69); duration of analgesia and motor block was also more. VAS scores in Group II were less compared to Group I. Rescue doses required in Group II were less compared to Group I. Conclusions: Addition of dextrose have proved to be effective in quick onset of sensory, motor blockade and longer duration of blockade and prolonged two segment regression time with no adverse side effects.