DSpace logo

Please use this identifier to cite or link to this item: http://172.16.4.202:8080/xmlui/handle/123456789/8407
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMadhuri ArcotaAzeemMohiyuddin S.M. Sharath B.-
dc.date.accessioned2023-12-07T06:47:17Z-
dc.date.available2023-12-07T06:47:17Z-
dc.date.issued2020-01-
dc.identifier.urihttp://172.16.4.202:8080/xmlui/handle/123456789/8407-
dc.description.abstractObjective: The aim of this study was to determine the association of EGLN1 gene variant SNP rs479200 (T>C) with the risk of oral cancer. Materials and methods: A case-control study was conducted by involving 103 oral cancer patients and 206 age and gender-matched healthy controls. SNP rs479200 was genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Results: Minor allele frequency was 47 % in oral cancer patients and 35 % in healthy individual (P = 3.0 × 10−3, Odds ratio = 1.61). The association was highest under the additive genetic model (0.0005). Conclusions: Our results show that the EGLN1 gene variant SNP rs479200 is associated with the risk of developing oral cancer. This relationship highlights the significance of oxygen sensing in the pathophysiology of oral cancer.en_US
dc.language.isoenen_US
dc.subjectOral cancer Hypoxia Genetic Association Study EGLN1 gene Single nucleotide polymorphismen_US
dc.titleHypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patientsen_US
dc.typeArticleen_US
Appears in Collections:Cell Biology & Molecular Genetics

Files in This Item:
File Description SizeFormat 
Hypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patients.pdf715.65 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.