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DC Field | Value | Language |
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dc.contributor.author | K Chengalvala, K Prabhavathi, KV Venkateshu, SR Sheela, R Kalyani, CV Raghuveer, P Kiranmayee. | - |
dc.date.accessioned | 2023-12-06T10:39:33Z | - |
dc.date.available | 2023-12-06T10:39:33Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.uri | http://172.16.4.202:8080/xmlui/handle/123456789/8388 | - |
dc.description.abstract | The aim and objectives of the study were to determine (i) whether a high serum fluoride (F) level was an added risk factor for the development of pre-eclampsia in Kolar population, an area with endemic fluorosis, and (ii) whether the serum F levels could be used as a predictive diagnostic marker for pre-eclampsia. The study was designed as a case–control study in pregnant women after 20th week of gestation in the Department of Obstetrics and Gynecology of a tertiary care hospital. After obtaining ethics clearance and written informed consent from 300 pregnant women (150 cases and 150 controls), 5 mL of venous maternal blood was collected in a plain (red-capped) vacutainer and serum was separated for estimation of the serum F levels by using a fluoride ion-selective electrode. The serum F levels in the cases and controls were statistically analyzed by the Mann-Whitney U test. The mean±standard deviation in the cases and controls was 1.8±0.66 and 0.18±0.31 mg/L, respectively. The serum F levels were significantly higher in the pre-eclampsia cases with a z value of 14.4. We found that F is an added risk factor for pre-eclampsia and that a maternal serum F level of ≥1.8 mg/ L can be considered as a diagnostic biomarker for predicting pre-eclampsia and the related pregnancy outcomes. | en_US |
dc.language.iso | en | en_US |
dc.subject | Biomarker; Hypertension pregnancy outcomes; Pre-eclamptic women; Pregnancy; Serum fluoride. | en_US |
dc.title | SERUM FLUORIDE LEVELS AS A BIOMARKER IN PRE-ECLAMPTIC WOMEN: A CASE–CONTROL TERTIARY CARE HOSPITAL BASED STUDY | en_US |
dc.type | Article | en_US |
Appears in Collections: | Biochemistry |
Files in This Item:
File | Description | Size | Format | |
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SERUM FLUORIDE LEVELS AS A BIOMARKER IN PRE-ECLAMPTIC.pdf | 230.48 kB | Adobe PDF | View/Open |
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