Please use this identifier to cite or link to this item:
http://172.16.4.202:8080/xmlui/handle/123456789/8351
Title: | Effect of vitamin K epoxide reductase complex 1 polymorphism on warfarin dose requirement among patients in tertiary care hospital. |
Authors: | Sahana H, Veeregowda, Bhuvana K, Sharath B. |
Keywords: | Oral anticoagulant, Vitamin K epoxide reductase complex 1 polymorphism, warfarin |
Issue Date: | Feb-2020 |
Abstract: | Background: Warfarin, anticoagulant is used for thromboembolic disorders. Inter‑individual variation in clinical response to warfarin is due to various factors, including polymorphism of Vitamin K epoxide reductase complex 1 (VKORC1)‑1639G>A. The aim of our study was to evaluate the effect of VKORC1 polymorphism on the maintenance dose of warfarin. Materials and Methods: Cross‑sectional study conducted by the departments of Pharmacology, Cell Biology and Molecular Genetics on patients attending cardiology clinic, receiving warfarin for at least 2 months. Genomic deoxyribonucleic acid was extracted and genotyping was done by Polymerase Chain Reaction - Restriction Fragment Length Polymorphism. The correlation between VKORC1 gene polymorphism and warfarin maintenance dose was analyzed. Results: A total of 102 patients with a mean age of 47.72 ± 10.31 years, of which 58 (56.86%) were male. The frequency of VKORC1 G>A for GG, GA, and AA genotypes was 74.51%, 19.61%, and 5.88%, respectively. Variant allele AA was less frequent than the wild type. Mean weekly warfarin dose was 23.12 ± 8.08, 22.93 ± 8.21, and 15.6 ± 5.35 mg in patients with GG, GA, and AA genotypes, respectively. Patients with GG genotype required therapeutic dose compared to variant type (P = 0.001). Multiple stepwise regression model showed 26.3% variability in warfarin dose was due to VKORC1 genotype (R = 0.513, R2 = 0.263, adjusted R2 = 0.256, P = 0.0001). Conclusion: VKORC1 polymorphism alone influence 26.3% variability in warfarin dose and AA genotype patients required lower dose |
URI: | http://172.16.4.202:8080/xmlui/handle/123456789/8351 |
Appears in Collections: | Pharmacology |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Effect of vitamin K epoxide reductase complex 1 polymorphism on warfarin dose requirement among patients in tertiary care hospital..pdf | 719.91 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.