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http://172.16.4.202:8080/xmlui/handle/123456789/8348
Title: | Role of turmeric extract in minimising mucositis in patients receiving radiotherapy for head and neck squamous cell cancer: a randomised; placebo-controlled trail |
Authors: | P Arun, Sagayraj A, Azeem Mohiuddin SM, D Santhosh. |
Keywords: | Turmeric; Mucositis; Head And Neck Squamous Cell Carcinoma; Radiation; Chemoradiotherapy |
Issue Date: | Nov-2020 |
Abstract: | To determine the role of turmeric extract in reducing mucositis in patients undergoing radiotherapy for head and neck cancer. Methods. Sixty-one patients who underwent radiotherapy were included in the study and randomised into groups A and B. Patients in group A received 500 mg of turmeric extract (BCM- 95) thrice daily, while patients in group B received placebo until radiotherapy completion. All patients were assessed for oral mucositis on a weekly basis during treatment and two months post-treatment using the National Cancer Institute Common Terminology Criteria for Adverse Events and World Health Organization criteria. Results. Both groups had a similar grade of mucositis in first two weeks of treatment. The severity of mucositis was progressive in the control group, with four patients developing grade 3 mucositis by week four. In group A, however, the majority of patients (73.3 per cent) had grade 1 mucositis after four weeks of treatment. The difference was statistically significant from the third week onwards ( p < 0.001). Conclusion. Turmeric extract reduces the incidence and severity of radiation-induced mucositis, which can benefit patients undergoing radiation for head and neck cancer. |
URI: | http://172.16.4.202:8080/xmlui/handle/123456789/8348 |
Appears in Collections: | ENT |
Files in This Item:
File | Description | Size | Format | |
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Role of turmeric extract in minimising mucositis in patients receiving radiotherapy for head and neck squamous cell cancer a randomised; placebo-controlled trail..pdf | 207.43 kB | Adobe PDF | View/Open |
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