COMPARATIVE STUDY OF ENDOSCOPIC RAPID UREASE TEST WITH SEROLOGY OF HELICOBACTER PYLORI INFECTION IN ACID PEPTIC DISEASE

Abstract

BACKGROUND: APD is world wide health issue for the surgeons, mainly due to risk and associated complications like GU, DU, GIT perforation etc. this aims at early detection of disease which is caused by HP and intervention prevents the further complications. METHODS: This study is conducted in the endoscopic unit of department of General Surgery in R.L.Jalappa hospital and research centre in patients with APD in the year 2019-2021. All the patients suitable for the study in regards to the inclusion and exclusion crieteria are subjected to both the study until the samle size is achieved, with the prior agreement of the institutional ethical committee. RESULTS: All the participants are tested with RUT and ELISA and 87.60% had RUT positive and 86.78% had ELISA positive infection.RUT had sensitivity of 87.62% in predicting ELISA, specificity was 12.50%, with a total diagnostic accuracy of 77.69%. We treated 51.24% with the CMO kit and 48.76% with HP kit. On three-month follow up, 37.2% had recurrence of the disease with 33.87% in patients who are treated with CMO kit, and 40.68% among those treated with HP kit (p value 0.439). Based on Chi square test /Fisher's Exact test our study concluded that RUT to have good accuracy for predicting HP infections and after three month follow up CMO kit treatment was found to have less recurrence rate.