COMPARISON OF INTRAVENOUS TRANEXAMIC ACID VERSUS SUBLINGUAL MISOPROSTOL IN REDUCING BLOOD LOSS IN PATIENTS UNDERGOING CAESAREAN SECTION

Abstract

BACKGROUND: Caesarean section is the most often performed major surgeries on women all over the world. The most common caesarean section consequences are primary or secondary postpartum haemorrhage. It has the potential to raise maternal mortality and morbidity rates. AIM: To compare the effectiveness of intravenous tranexamic acid (TXA) and sublingual misoprostol in reducing blood loss in patients undergoing caesarean section. MATERIALS & METHODS: Conducted a randomized prospective control trial from January 2020 to June 2021. A total of 118 participants were enrolled in the study. RESULTS: The mean age identified in the TXA and misoprostol group were 24.12 ± 3.3 and 23.81 ± 3.64 respectively. The mean of mops count in the misoprostol and TXA group were noted as 4.73 ± 1.27 and 3.2 ± 1.45 respectively. Around 8.47% of the participants in the misoprostol group required uterotonics, whereas, 15.25% in the TXA group required uterotonics. The pre-operative and post-operative haemoglobin in the misoprostol group were identified as 11.67 ± 1.37 and 10.78 ± 1.12 whereas, it was identified as 11.76 ± 1.43 and 11.17 ± 1.4 in the TXA group. The common side effects identified in the misoprostol group was chills, vomiting and fever with 47.46%, 13.56% and 11.86% while, it was 11.86%, 5.08% and 3.39% in the TXA group. xv CONCLUSION: The present study concluded that the use of tranexamic acid significantly reduced the intraoperative and perioperative blood loss much better than misoprostol during caesarean section. Also tranexamic acid is better agent and can be administered routinely in patients undergoing caesarean section, as side effects of tranexamic acid were lesser than that of misoprostol. Hence tranexamic acid can be administered routinely in patients undergoing caesarean section.