CORRELATION OF POSTPRANDIAL DYSLIPIDEMIA AND GLYCEMIC CONTROL WITH CAROTID INTIMA MEDIA THICKNESS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

Background: In diabetic patients, the macrovascular disease is a major cause of death, and many diabetics have numerous atherosclerosis risk factors. Carotid-Intima Media Thickness (CIMT) is measured by ultrasonography, a non-invasive and quantitative method of evaluating early atherosclerotic changes in the vasculature. The current study aims to measure postprandial lipid profile, one-hour postprandial plasma glucose, HbA1C, and correlate with CIMT. Materials: This is an observational study conducted on type-2 diabetes mellitus patients attending RL Jalappa Hospitals, Kolar, from January 2020 to January 2021 selected in a randomized manner. Mean CIMT (in mm) is considered as the primary outcome variable. Post prandial blood sugar(mg/dl) and Hba1C (%) and triglycerides(mg/dl) are considered as primary explanatory variable. Results: A total of 65 patients with a mean age of 56.86 ± 11.89 years with 73.85% males, mean BMI 29.73 ± 4.03kg/m2 are included in the study. The mean fasting blood pressure is 137.35 ± 48.82 mg/dl; the mean-post prandial blood sugar is 267.78 ± 84.45 mg/dl, and the mean HBA1C is 7.67 ± 1.83(%), in our study. The mean triglycerides are 259.98 ± 111.46 mg/dl, the mean HDL cholesterol is 39.19 ± 11.31 mg/dl, the mean LDL cholesterol is 99.97 ± 27.26 mg/dl, and the mean total cholesterol is 191.16 ± 37.23 mg/dl. Mean CIMT is 2.73 ± 3.56 mm. Conclusion: There is a moderate positive correlation between postprandial triglycerides and CIMT in our study. There is a weak positive correlation between HBA1C, LDL cholesterol, xvi total cholesterol, and CIMT. There is a weak negative correlation between HDL cholesterol and CIMT. Only postprandial triglyceride (r-value 0.651, p-value: <0.001) has a better association with CIMT compared to other lipid parameters in our study.