EVALUATION OF EFFECT OF LOW DOSE DEXMEDITOMIDINE ON INTRAOPERATIVE HEMODYNAMICS IN PATIENTS UNDERGOING LAPAROSCOPIC SURGERIES UNDER GENERAL ANAESTHESIA

Abstract

BACKGROUND AND OBJECTIVE: INTRODUCTION: Dexmedetomidine has proved to provide adequate intraoperative analgesia and good surgical field, postoperative sedation, and patient comfort with no adverse effects for patients. Dexmedetomidine helps in blunting hemodynamic changes in response to laryngoscopy, tracheal intubation, pneumoperitoneum and extubation in the perioperative period due to the sympatholytic activity. OBJECTIVES: To assess the hemodynamic stability with the two different dose of dexmedetomidine (0.25mcg & 0.5mcg) among patients experiencing laparoscopic surgeries under general anaesthesia. METHODOLOGY: This is Prospective observational study done among 64 Patients admitted under General Anaesthesia for elective laparoscopic surgeries performed at R. L. Jalappa Hospital and Research centre, Tamaka, Kolar during the interval between January 2020 to May 2021. They were classified into two groups, Group A (Dexmed- 0.25mcg/kg/hr) and Group B (Dexmed -0.5mcg/kg/hr). Haemodynamic changes were examined among the two groups. XVIII RESULTS: The differences in Baseline characteristics of the study groups were not statistically significant except the ASA grade. The difference in means of the haemodynamic parameters such as Heart rate, systolic-blood pressure, diastolic-blood pressure, mean-arterial pressure, and oxygen saturation were between the study groups were not statistically significant except the systolic-blood pressure at 90 min, where the mean SBP is significantly greater among Group A (Dexmed- 0.25mcg). CONCLUSION: From this study, we conclude that there is no difference in hemodynamic stability with two different doses of dexmedetomidine(0.25mcg & 0.5mcg) among patients underwent laparoscopic surgeries under general anaesthesia. We did not see any majorly adverse side effects in both the groups, with the haemodynamically stability with the two separate doses of dexmedetomidine, the drug can be used with any of the doses, depending upon the desired effect.