ROLE OF XANTHINE OXIDASE AND URIC ACID IN METABOLIC SYNDROME

Abstract

BACKGROUND: Patients with metabolic syndrome are at a high risk of developing diabetes and CVD; therefore, early intervention, primarily lifestyle modifications, can ultimately prevent these costly and deadly diseases. AIMS: To determine the role of xanthine oxidase and uric acid in metabolic syndrome. MATERIALS & METHODS: Cross-sectional, hospital-based observational study conducted for a period of one and half year from January 2019 to July 2020 in a population of 128 participants. RESULTS: The mean age of participants was 55.64±12.61 years. Majority of the participants in the study population were males with 61.72%. Fasting blood sugar, uric acid and serum xanthine oxidase were identified with 172.21 ± 87.42, 7.58 ± 0.74 and 2.99 ± 0.91 in participants with the metabolic syndrome. The Uric Acid was ≥7.35 for 70.31% participants with metabolic syndrome. Whereas, the Serum xanthine oxidase was ≥1.95 for 88.71% of participants. The uric acid had sensitivity, specificity, false positive rate, false-negative rate, positive predictive value, negative predictive value and total diagnostic accuracy of 70.31%, 76.56%, 23.44%, 29.69%, 75%, 72.06% and 73.44% in predicting the presence of the metabolic syndrome. The serum xanthine oxidase had sensitivity, specificity, false positive rate, false-negative rate, positive predictive value, negative predictive value and total diagnostic accuracy of 88.71%, 90.63%, 9.38%, 11.29%, 90.16%, 89.23% and 89.68% in predicting the presence of the metabolic syndrome. xii Conclusion: A strong association was found between uric acid, xanthine oxidase and prevalence of metabolic syndrome. This also indicated that the waist circumference, uric acid, serum xanthine oxidase and HDL levels can indicate the risk of developing metabolic syndrome.