STUDY OF MARKERS OF DYSLIPIDEMIA AS RISK FACTORS IN ACUTE CORONARY SYNDROME

Abstract

INTRODUCTION & OBJECTIVES: Obesity and changing lifestyle habits and sedentary nature of jobs have led to the increasing trend of morbidity and mortality around the world. Dyslipidemia is one the most commonly associated modifiable risk factor identified. It has always been a notion of Apo-B being better than LDL-C, Non-HDL-C as being the risk factor for the development of CAD, but the Indian studies have shown the gene polymorphism has paved way to the Apo- B being lower than Non- HDL-C even in patients with diagnosed cardiac disease. This was a study undertaken to see for the correlation of risk factors of dyslipidemia with acute coronary syndrome concentrating mainly on Apo-B versus LDL-C and Non-HDL-C in Acute coronary syndrome. MATERIALS AND METHODS: This is a prospective observational study involving 113 patients who were diagnosed with Coronary artery disease. Blood sample of 5 ml was collected and sent for extended lipid profile which included parameters such as LDL-C, Non- HDL-C, Apo-A, Apo-B. Informed written consent was obtained from the study subjects. RESULTS: It is observed that Non- HDL-C is a better predictor than Apo-B and LDL-C. Mean age of the study group was 58. 6 + 11.05 years with a preponderance of males (74.3%) when compared to females (25.7%). The study subjects included major complaints of chest pain (60.2%). Correlation between Non HDL-C and Apo-B was seen to have Pearson correlation coefficient of 0.477 (p- value<0.001). CONLUSION: The above study suggests that Non- HDL-C is a much better predictor compared to LDL-C or Apo-B, which supports its utility as a correlation with Acute coronary syndrome.