Evaluation of Biochemical Parameters evincing atherogenic potency in Type 2 Diabeticd Retinopathy

Abstract

Objectives- Poor glycemic control leads to hypomagnesemia, uncontrolled hyperglycemia associated with high incidence of micro vascular complications such as retinopathy, nephropathy and cardiovascular problems in type 2 Diabetes mellitus. The chief aim of the study is to obtain possible biochemical indices level in all the groups. Materials and methodsThe current study was under taken in total 90 subjects divided in to three groups, includes thirty control (Group-1), thirty diabetics with out complications of retinopathy (Group-2) and thirty diabetics with retinopathy (Group-3). Fasting Blood sugar level, fructosamine, magnesium, microalbuminuria, cholesterol, triglycerides, LDL-cholesterol and HDLcholesterol were analyzed in all the groups. Results-Decreased serum magnesium observed in Group-3 compared to Group-1 was a significant observation and also significant correlation present between fructosamine, magnesium and microalbuminuria level. Our study results also indicate that the diabetic retinopathy patients have hypercholesterolemia, hypertriglyceridemia, elevated LDL-cholesterol lipoprotein fraction and significantly decreased HDL-cholesterol lipoprotein fraction which are responsible for micro vascular changes. Conclusion- Hypomagnesemia, hyperglycemia, increased fructosamine and increased lipid profile with decreased HDL-cholesterol level indicates the probability and possibility of atherogenicity